Naringin Activates Semaphorin 3A to Ameliorate TGF-β-induced Endothelial-to-Mesenchymal Transition Related to Atrial Fibrillation.

YJ Lai, SH Chang, YC Tung, GJ Chang, C De Almeida, WJ Chen, YH Yeh, FC Tsai

J. Cell. Physiol. 2024 Mar; doi: 10.1002/jcp.31248 (SCI, IF=5.6, 9/79; Physiology)

 

CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca2+-handling abnormalities: implication in cardiac arrhythmias.

YH Chan, FC Tsai, GJ Chang, YJ Lai, SH Chang, WJ Chen, YH Yeh

J Biomed Sci. 2023 Jul 14;30(1):55. doi: 10.1186/s12929-023-00944-0. (SCI, IF=11, 13/136; Medicine, Research & Experimental)

 

High-phosphate diet causes atrial remodeling and increases atrial fibrillation vulnerability via STAT3/NF-κB signaling and oxidative stress.

YJ Hsu, GJ Chang, YJ Lai, YH Chan, WJ Chen, CT Kuo, YH Yeh

Acta Physiol (Oxf). 2023 Jun;238(2):e13964. doi: 10.1111/apha.13964. (SCI, IF=6.3, 6/79; Physiology)

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Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access.

CJ Chang, YJ Lai, YC Tung, LS Wu, LA Hsu, CN Tseng, GJ Chang, KC Yang, YH Yeh

Kidney Int. 2023 Apr;103(4):702-718. doi: 10.1016/j.kint.2022.12.022. (SCI, IF=19.6, 3/88; Urology & Nephrology)

 

Cathepsin S Inhibition Suppresses Experimental Systemic Lupus Erythematosus-Associated Pulmonary Arterial Remodeling.

TH Yen, WJ Ho, YH Yeh, YJ Lai*. 

Int. J. Mol. Sci. 2022 Oct 14;23(20):12316. doi: 10.3390/ijms232012316 (SCI, IF=5.6, 66/285; Biochemistry & Molecular Biology)

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MiR-181b targets semaphorin 3a to mediate TGF-β-induced endothelial-to-mesenchymal transition related to atrial fibrillation.

YJ Lai, FC Tsai, GJ Chang, SH Chang, CC Huang, WJ Chen, YH Yeh.

J Clin Invest. 2022 Jul 1;132(13):e142548. doi: 10.1172/JCI142548. (SCI, IF=19.456, 2/136;Medicine, Research &Experimental)

 

Candesartan cilexetil attenuates arrhythmogenicity following pressure overload in rats via the modulation of cardiac electrical and structural remodeling and calcium handling dysfunction.

GJ Chang, YH Yeh, WJ Chen, YS Ko, YJ Lai, YS Lee.

J Am Heart Assoc. 2022 Aug 2;11(15):e024285. doi: 10.1161/JAHA.121.024285. (SCI, IF=5.4, 39/142;Cardiac & Cardiovascular Systems)

 

Lumican deficiency promotes pulmonary arterial remodeling. 

YJ Lai*, Winston WY Kao, YH Yeh, WJ Chen, PH Chu.

Translational research. 2021 Nov;237:63-81. doi: 10.1016/j.trsl.2021.05.007. (SCI, IF=7.8, 3/29; Medical Laboratory Technology)

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Sirolimus Suppresses Phosphorylation of Cofilin and Reduces Interstitial Septal Thickness in Sporadic Lymphangioleiomyomatosis.

YL Huang, PR Chen, YJ Lai*, and HH Hsu.

Int. J. Mol. Sci. 2021 Aug 9;22(16):8564. doi: 10.3390/ijms22168564. (SCI, IF=5.6, 66/285; Biochemistry & Molecular Biology)

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Effects of positive end-expiratory pressure on the predictability of fluid responsiveness in acute respiratory distress syndrome patients. 

YH Chen, YJ Lai, CY Huang, HL Lin, CC Huang.

Sci Rep. 2021 May 13;11(1):10186. doi: 10.1038/s41598-021-89463-2. (SCI, IF=4.6, 22/73; Multidisciplinary Sciences)

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CREB/ATF3 signaling mediates indoxyl sulfate-induced vascular smooth muscle cell proliferation and neointimal formation in uremia. WJ Chen, YJ Lai , JL Lee, ST Wu, YJ Hsu.

Atherosclerosis. 2020 Dec;315:43-54. doi: 10.1016/j.atherosclerosis.2020.11.09. (SCI, IF=5.3, 19/67; Peripheral vascular disease)

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Ubiquitin Pathway Is Associated with Worsening Left Ventricle Function after Mitral Valve Repair: A Global Gene Expression Study. 

FC Tsai, GJ Chang, YJ Lai , SH Chang, WJ Chen and YH Yeh.

Int. J. Mol. Sci. 2020 Jul 18; 21(14): 5073. doi: doi.org/10.3390/ijms21145073. (SCI, IF=5.6, 66/285; Biochemistry and Molecular Biology)

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Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease.

CJ Chang, CC Huang, PR Chen and YJ Lai*.

Int. J. Mol. Sci. 2020 Jun 30;21(13):4676. doi:10.3390/ijms21134676. (SCI, IF=5.6, 66/285; Biochemistry and Molecular Biology)

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Unique Wreath-like Smooth Muscle Proliferation of the Pulmonary Vasculature and Decreased GCN2 Level in Pulmonary Veno-Occlusive Disease versus Pulmonary Arterial Hypertension.

YJ Lai, PR Chen, YL Huang, HH Hsu.

Journal of the Formosan Medical Association. 2020 Jan;119(1 Pt 2):300-309. doi: 10.1016/j.jfma.2019.05.019(SCI, IF=3.2, 69/167; Medicine, General & Internal)

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Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling.

WJ Chen, SH Chang, YH Chan, JL Lee, YJ Lai, GJ Chang, FC Tsai, YH Yeh. 

J. Mol. Cell. Cardiol. 2019 Oct, 135: 67-78. doi: 10.1016/j.yjmcc.2019.08.006 (SCI, IF=5, 43/142; Cardiac & Cardiovascular Systems)

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Atrial fibrillation and its arrhythmogenesis associated withinsulin resistance. 

YH Chan, GJ Chang, YJ Lai, WJ Chen, SH Chang, LM Hung, CT Kuo & YH Yeh.

Cardiovascular Diabetology. 2019 Sep 26;18(1):125. doi: 10.1186/s12933-019-0928-8 (SCI, IF=9.3, 10/145; Endocrinology & Metabolism).

Cathepsin S Promotes the Development of Pulmonary Arterial Hypertension. 

CJ Chang, HC Hsu, WJ Ho, GJ Chang, JHS. Pang, WJ Chen, CC Huang, YJ Lai*.

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L1-L13. doi: 10.1152/ajplung.00530.2018. (SCI, IF=4.9, 13/79; Physiology)

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EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension.

YJ Lai *, IC Chen, HH Li, CC Huang.

Int. J. Mol. Sci. 2018 Mar 3;19(3):727. doi: 10.3390/ijms19030727. (SCI, IF=5.6, 66/285; Biochemistry and Molecular Biology)

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Prostanoid EP4 Agonist L-902,688 Activates PPARγ and Attenuates Pulmonary Arterial Hypertension. 

HH Li, HH Hsu, GJ Chang, IC Chen, WJ Ho, PC Hsu, WJ Chen, JHS. Pang, CC Huang, YJ Lai*. 

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L349-L359. doi: 10.1152/ajplung.00245.2017 (SCI, IF=4.9, 13/79; Physiology)

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Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway. YJ Lai,*, HH Hsu, GJ Chang, SH Lin, WJ Chen, CC Huang, JHS. Pang*. 

Sci Rep. 2017 Aug 30;7(1):9974. doi: 10.1038/s41598-017-09707-y(SCI, IF=4.6, 22/73 Multidisciplinary Sciences)

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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.

NF Tojais, A Cao, YJ Lai, L Wang, PI Chen, MAA Alcazar, V de Jesus Perez, RK Hopper, CJ Rhodes, MA Bill, LY Sakai, M Rabinovitch.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1559-1569. doi: 10.1161/ATVBAHA.117.309696 (SCI, IF=8.7, 6/67; Peripheral Vascular Disease)

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GT-repeat length polymorphism in heme oxygenase-1 promoter determines the effect of cilostazol on vascular smooth muscle cells. 

WJ Chen , YH Chen, YJ Lai, YJ Hsu, YH Yeh, CS Tsai, CY Lin. 

Int J Cardiol. 2016 Nov 1;222:407-415. doi: 10.1016/j.ijcard.2016.07.234 (SCI, IF=3.5, 62/142; Cardiac & Cardiovascular Systems)

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Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase. YJ Lai, GJ Chang, YH Yeh, JH S. Pang, CC Huang, WJ Chen*.

PLoS ONE. 2015 Sep 14, 10(9): e0137426. doi: 10.1371/journal.pone.0137426 (SCI, IF=3.7, 29/73; Multidisciplinary Sciences)

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Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway.

YH Yeh, CT Kuo, GJ Chang, YH Chen, YJ  Lai, ML Cheng, Chen WJ.

J Mol Cell Cardio. 2015 May;82:84-92. doi: 10.1016/j.yjmcc.2015.03.004 (SCI, IF=5, 43/142; Cardiac & Cardiovascular Systems)

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Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. 

H Sawada, T Saito, N P Nickel, TP Alastalo, JP Glotzbach, R Chan, L Haghighat, G Fuchs, M Januszyk, A Cao, YJ Lai, V de Jesus Perez, YM Kim, Ll Wang, PI Chen, E Spiekerkoetter, Y Mitani, GC Gurtner, P Sarnow, M Rabinovitch.

J. Exp. Med. 2014 Feb 10;211(2):263-80. doi: 0.1084/jem.20111741 (SCI, IF=15.3, 4/136; Medicine, Research & Experimental)

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Rhodiola: an ordinary plant or a promising future therapy for pulmonary hypertension? 

D Kosanovic, X Tian, O Pak, YJ Lai, YL Hsieh, M Seimetz, N Weissmann, R T Schermuly, BK Dahal.

Pulm Circ. 2013 Sep; 3(3): 499–506. doi: 10.1086/674303 (SCI, IF=2.6, 86/142; Cardiac & Cardiovascular Systems)

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In vivo and in vitro inhibitory effects of a traditional Chinese formulation on LPS-stimulated leukocyte-endothelial cell adhesion and VCAM-1 gene expression.

YH Wu, SY Chuang, WC Hong, YJ Lai, YL Chang, JH Pang.

J Ethnopharmacol. 2012 Mar 6; 140(1): 55-63. doi: 10.1016/j.jep.2011.12.002 (SCI, IF=5.4, 4/28; Integrative & Complementary Medicine)

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Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. 

YH Wu, SY Chuang, WC Hong, YJ Lai, GJ Chang and JH Pang.

Int J Immunopathol Pharmacol. 2012 Jul-Sep;25(3):741-50. doi: 10.1016/j.jep.2011.12.002 (SCI, IF=3.5, 25/76; Pathology)

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Bone Morphogenetic Protein Promotes Motility and Represses Proliferation of Vascular Smooth Muscle Cells by Tandem Recruitment of Wnt Pathways. 

De Jesus Perez V, Z Ali, TP Alastalo, F Ikeno, H Sawada, YJ Lai, T Kleisli, E Spiekerkoetter, X Qu, LH Rubinos, E Ashley, M Amieva, S Dedhar and M Rabinovitch.

J Cell Biol. 2011 Jan 10;192(1):171-88. doi: 10.1083/jcb.201008060 (SCI, IF=7.8, 39/191; Cell Biology)

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Therapeutic Efficacy of Azaindole-1 In Experimental Pulmonary Hypertension.

BK Dahal, D Kosanovic, PK Pamarthi, A Sydykov, YJ Lai, R Kast, H Schirok, JP Stasch, HA Ghofrani, N Weissmann, F Grimminger, W Seeger, RT Schermuly.

Eur Respir J. 2010 Oct;36(4):808-18. doi: 10.1183/09031936.00140309 (SCI, IF=24.3, 3/65; Respiratory System)

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Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.

YJ Lai, SS Pullamsetti, E Dony, N Weissmann, G Butrous, GA Banat, HA Ghofrani, W Seeger, F Grimminger, RT Schermuly.

Am J Respir Crit Care Med. 2008 Jul 15;178(2):188-96. doi: 10.1164/rccm.200710-1519OC (SCI, IF=30.528, 3/65; Respiratory System)

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Partial reversal of experimental pulmonary hypertension by phosphodiesterase 3/4 inhibition. 

E Dony, YJ Lai, R Dumitrascu, SS Pullamsetti, R Savai, HA Ghofrani, N Weissmann, C Schudt, D Flockerzi, W Seeger, F Grimminger, RT Schermuly.

Eur Respir J. 2008 Mar;31(3):599-610. doi: 10.1183/09031936.00002007 (SCI, IF=33.809, 2/65; Respiratory System)

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Reversal of experimental pulmonary hypertension by PDGF inhibition.

RT Schermuly, E Dony, HA Ghofrani, SS Pullamsetti, R Savai, M Roth, A Sydykov, YJ Lai, N Weissmann, W Seeger, F Grimminger.

J Clin Invest. 2005 Oct;115(10):2811-21. doi: 10.1172/JCI24838 (SCI, IF=15.9, 3/136; Medicine, Research &Experimental)

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Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogensis in Cholesterol-Fed Rabbits: PTEN Induction and Inhibition of Vascular Smooth Muscle Cell Proliferation and Migration Circulation. 

WJ Chen, KH Lin, YJ Lai, SH Yang, and JH S Pang.

Circulation. 2004 Sep 7; 110(10):1313-9. doi: 10.1161/01.CIR.0000140764.15398.F3 (SCI, IF=37.8, 1/67; Peripheral Vascular Disease)

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